PEMODELAN SENYAWA PHALERIN BERTANDA 125I UNTUK UJI ANTIRADANG

Abstract

A model of ¹²⁵I-phalerin was designed in this research. The work was started by designing phalerin based on available data and followed by minimizing energy at bond angles, i.e C4-05-C7-C8 (0 ) ^{, C5-C7-C8-C9 (2),C3-014-C15-C20 (3) and C4-C3-014-C15 (4).This work was then continued with designing of 115l -phalerin. Both models were put in overlaid position, then they were characterized. Result showed that phalerin model has characteristic of bond angle with 1} z 3, 4= 40°, 40°, 320°, 280° respectively. Energy ofphalerin model was 18,7625 kkal/mol. "51-phalern has similarity conformation with phalerin and the RMS for bond length, bond angle 0.0091 a and 0.5039° respectively.